Keyword Analysis & Research: finerenone

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What is finefinerenone used for?

Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor (MRA) with anti-inflammatory and antifibrotic effects. It is thought to have higher potency and less hyperkalemia than steroidal MRAs such as spironolactone and eplerenone.

What is the molecular formula of finerenone?

The molecular formula is C 21 H 22 N 4 O 3 and the molecular weight is 378.43 g/mol. The structural formula is: Finerenone is a white to yellow crystalline powder. It is practically insoluble in water; and sparingly soluble in 0.1 M HCl, ethanol, and acetone.

Does Finerenone reduce albuminuria in patients with chronic kidney disease?

List of authors. Finerenone, a nonsteroidal, selective mineralocorticoid receptor antagonist, reduced albuminuria in short-term trials involving patients with chronic kidney disease (CKD) and type 2 diabetes. However, its long-term effects on kidney and cardiovascular outcomes are unknown.

Is finefinerenone non-genotoxic?

Finerenone was non-genotoxic in an in vitro bacterial reverse mutation (Ames) assay, the in vitro chromosomal aberration assay in cultured Chinese hamster V79 cells, or the in vivo micronucleus assay in mice.

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